Detailed view for PF3D7_1219000

Basic information

TDR Targets ID: 5234
Plasmodium falciparum, formin 2
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.0049 | Length (AA): 2974 | MW (Da): 349765 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02181   Formin Homology 2 Domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0000910   cytokinesis  
GO:0005575   cellular_component  
GO:0003779   actin binding  
GO:0030036   actin cytoskeleton organization and biogenesis  
GO:0016043   cellular component organization and biogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 27 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2408 2787 1ux5 (A) 1360 1754 21.00 0.000000000014 1 0.25 0.38
2470 2798 1v9d (A) 830 1153 25.00 0 1 0.36 -0.58
328 1411 3s5h (A) 69 1184 17.00 0.000000027 0.89 0.345292 0.99
1009 2151 4zt9 (A) 76 1311 15.00 0.054 0.77 0.337131 1.45
1088 1758 5czz (A) 406 1049 24.00 0.12 0.93 0.125622 1.82
1281 1574 4hte (A) 260 589 27.00 0.16 0.87 0.209857 0.15
1431 1625 1xkz (A) 338 518 32.00 0.021 0.19 0.255568 -0.02
1431 1589 1xa1 (D) 8 208 34.00 0.27 0.14 0.155463 0.21
1462 2295 1s0f (A) 275 1164 24.00 0.41 0.97 0.22643 1.7
2096 2313 4tql (A) 12 238 26.00 0.065 0.65 0.397302 -0.9
2162 2309 3gty (X) 217 362 30.00 0.27 0.12 0.261765 0.09
2394 2786 4eah (A) 562 938 27.00 0.000000000055 1 0.358145 0.33
2398 2822 3obv (E) 754 1179 25.00 0 1 0.280705 0.63
2410 2754 2z6e (C) 614 969 32.00 0 0.78 0.281005 1.02
2470 2779 1v9d (C) 830 1134 28.00 0.000013 1 0.161237 0.32
2677 2865 4uos (A) 3 183 20.00 0.15 0.05 0.192351 -0.43
708 1486 3s5m (A) 190 997 20.00 0.25 0.79 0.220173 1.4
1284 1577 4hte (A) 260 589 26.00 0.31 0.84 0.178257 0.34
1357 1610 4k2u (B) 9 282 18.00 0.53 0.01 0.251721 -0.52
1434 1592 1xa1 (D) 8 208 34.00 0.44 0.22 0.147909 0.37
2165 2312 3gty (X) 217 362 30.00 0.31 0.43 0.282214 0.2
2407 2824 3o4x (E) 747 1178 24.00 0 1 0.32281 0.61
2411 2850 3o4x (E) 764 1198 22.00 0 1 0.0125998 0.62
2413 2757 2z6e (C) 614 969 32.00 0 0.86 0.285388 1.06
2473 2782 1v9d (C) 830 1134 28.00 0.000012 1 0.161632 0.32
2680 2868 4uos (A) 3 183 20.00 0.092 0.05 0.194887 -0.43
2851 2974 3na7 (A) 13 138 12.00 0.54 0 0.220553 -1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 16 hs, early trophozoite, late ring, late schizont, late trophozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early schizont, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 32 hs, gametocyte. Otto TD PlasmoDB
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_152384)

Species Accession Gene Product
Babesia bovis BBOV_IV007290   formin homology 2 domain containing protein
Plasmodium berghei PBANKA_1434600   formin 2, putative
Plasmodium falciparum PF3D7_1219000   formin 2
Plasmodium knowlesi PKNH_1438600   formin 2, putative
Plasmodium vivax PVX_123615   formin 2, putative
Plasmodium yoelii PY01855   Formin Homology 2 Domain, putative
Theileria parva TP03_0237   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1219000 (Plasmodium falciparum), formin 2
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